N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids

Why this matters, in plain language

Bile and certain fatty acids — both signals that a bacterium has reached a human gut — turn the cholera toxin switch down rather than up. This paper identified the part of the regulator those signals act on, showing the switch reads its surroundings rather than simply firing.